holocytochrome-c synthase | |||||||
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Identifiers | |||||||
EC number | 4.4.1.17 | ||||||
CAS number | 75139-03-6 | ||||||
Databases | |||||||
IntEnz | IntEnz view | ||||||
BRENDA | BRENDA entry | ||||||
ExPASy | NiceZyme view | ||||||
KEGG | KEGG entry | ||||||
MetaCyc | metabolic pathway | ||||||
PRIAM | profile | ||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||
Gene Ontology | AmiGO / EGO | ||||||
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Cytochrome c/c1 heme lyase | |||||||||
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Identifiers | |||||||||
Symbol | Cyto_heme_lyase | ||||||||
Pfam | PF01265 | ||||||||
InterPro | IPR000511 | ||||||||
PROSITE | PDOC00647 | ||||||||
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In enzymology, a holocytochrome-c synthase (EC 4.4.1.17) is an enzyme that catalyzes the chemical reaction
Hence, this enzyme has one substrate, holocytochrome c, and two products, apocytochrome c and heme.
This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is holocytochrome-c apocytochrome-c-lyase (heme-forming). Other names in common use include cytochrome c heme-lyase, holocytochrome c synthetase, and holocytochrome-c apocytochrome-c-lyase. This enzyme participates in porphyrin and chlorophyll metabolism.
Cytochrome c haem-lyase (CCHL) and cytochrome Cc1 haem-lyase (CC1HL) are mitochondrial enzymes that catalyse the covalent attachment of a haem group on two cysteine residues of cytochrome c and c1. These two enzymes are functionally and evolutionary related. There are two conserved regions, the first is located in the central section and the second in the C-terminal section. Both patterns contain conserved histidine, tryptophan and acidic residues which could be important for the interaction of the enzymes with the apoproteins and/or the haem group.[1]
This article incorporates text from the public domain Pfam and InterPro IPR000511